Postdoctoral Associate: Host–Microbe Interactions
Durham, North Carolina, USA
The Surana lab is looking for an energetic and motivated postdoctoral fellow who is interested in characterizing causal host–microbiota–immune interactions. The Surana laboratory innovatively integrates gnotobiotic mouse models, microbiology, immunology, and bioinformatics to tackle medically relevant questions. We have recently developed a novel approach of microbe–phenotype triangulation that facilitates the identification of specific bacteria within the microbiota that are causally related to a phenotype of interest (Nature 2017). We interrogate these host–bacterial interactions from both the host (i.e., elucidating the immunological mechanism) and bacterial perspectives (i.e., identifying the necessary bacterial factors) using a combination of immunophenotyping, bacterial genetics, and various mouse models of disease. Active projects in lab relate to specific commensal bacteria that modulate inflammatory conditions, metabolic disorders, enteric infections, and viral infections. We have identified the commensal-derived bioactive molecule in several of these examples, with characterization of these molecules ongoing. There are also opportunities for translational projects that involve patient samples.
The Surana lab is part of the Departments of Pediatrics, Molecular Genetics and Microbiology, Immunology, and Cell Biology at Duke University School of Medicine. The lab is also affiliated with numerous centers on campus that offer a rich multidisciplinary environment, with active collaborations between clinicians and basic scientists. There are ample opportunities for formal and informal mentorship, with an eye towards ensuring scientific independence and career development.
- M.D. and/or Ph.D. (or equivalent) in biomedical sciences with a strong publication record
- Keen interest in host–microbiota interactions
- Robust background in microbiology and/or immunology
- Experience with bioinformatics (e.g., 16S rRNA sequencing, metagenomics, RNAseq) is preferred but not required
- Strong communication (oral and written English) and organizational skills
- Capable of driving projects forward while also being supportive of other team members
- Willingness to work with mice, with prior experience being beneficial
If interested, please send a cover letter with a statement of research interests and a CV to email@example.com. I am also happy to meet with people during the conference to discuss the opportunity in more detail.
Posting ID: 126