Guest Sessions

Mucosal Immunity, Microbiome, and Aging

Chairs

• Mulualem E. Tilahun, NIA, NIH
• Elizabeth J. Kovacs, Univ. of Colorado, Denver

Speakers

• Elizabeth J. Kovacs, Univ. of Colorado, Denver, Inflammaging, burn trauma, and the gut-lung axis
• Marta Rodriguez-Garcia, Tufts Univ. Sch. of Med., Aging compromises neutrophil-mediated innate protection against HIV in the human female genital tract
• Noah W. Palm, Yale Sch. of Med., Mapping uncharted landscapes of host-microbiota communication
• Yanjiao Zhou, Univ. of Connecticut Sch. of Med., The gut microbiome and immune responses in young and old mice on an intermittent-fasting diet

Immune Competence in Tissues

Chairs

• Dietmar Zehn, Tech. Univ. of Munich, Germany
• Georg Gasteiger, Max-Planck Res. Group for Systems Immunology, Univ. of Würzburg, Germany

Speakers

• Dietmar Zehn, Tech. Univ. of Munich, Germany, Dynamics and maintenance of resident CD8⁺ T cells in the intestine
• Georg Gasteiger, Max-Planck Res. Group for Systems Immunology, Univ. of Würzburg, Germany, Tissue niches of resident lymphocytes
• Wolfgang Kastenmüller, Max-Planck Res. Group for Systems Immunology, Univ. of Würzburg, Germany, Spatiotemporal orchestration of cellular immunity
• Christine S. Falk, Medizinische Hochschule Hannover, Germany, T and NK cell chimerism in human lung transplantation

Neuroimmune Interactions in CNS Development, Repair, and Disease

Chairs

• Francisco J. Quintana, Harvard Med. Sch.
• Nicola J. Allen, Salk Inst. for Biological Studies

Speakers

• Nicola J. Allen, Salk Inst. for Biological Studies, Astrocyte-neuron interaction in health and disease
• Michael V. Sofroniew, Univ. of California, Los Angeles, Diverse astrocyte roles in CNS innate immunity
• John R Lukens, Univ. of Virginia, SYKO mode: SYK is a key regulator of neuroprotective immune responses in Alzheimer’s disease
• Francisco J. Quintana, Harvard Med. Sch., Regulatory cell interactions in CNS inflammation

Protecting the Barrier from Invaders

Chairs

• Gretchen E. Diehl, Mem. Sloan Kettering Cancer Ctr.
• Kathryn A. Knoop, Mayo Clin.

Speakers

• Gretchen E. Diehl, Mem. Sloan Kettering Cancer Ctr., Commensal regulation of gut immunity to pathogens
• Kathryn A. Knoop, Mayo Clin., Early life protection in the intestine
• Amanda M. Jamieson, Brown Univ., Polymicrobial lung infections
• Nichole R. Klatt, Univ. of Minnesota Med. Sch., Vaginal microbiome and HIV infection

NK Cells and ILCs in Cancer

Chairs

• Todd A. Fehniger, Washington Univ. Sch. of Med. in St. Louis
• Mariapia A. Degli-Esposti, Monash Univ., Australia

Speakers

• Karl-Johan Malmberg, Univ. of Oslo, Norway, Transfer learning reveals NK cell states in the tumor microenvironment
• John B. Sunwoo, Stanford Univ. Sch. of Med., CD103⁺ NK cells and cancer
• Mariapia A. Degli-Esposti, Monash Univ., Australia, Regulatory roles of NK cells in infection and cancer
• Heather M. McGee, City of Hope Nat. Med. Ctr., Radiation-induced innate lymphoid cell activation in the liver tumor microenvironment

Location Matters: The Evolving Roles of Cell-autonomous and Local Complement

Chairs

• Ben Afzali, NIDDK, NIH
• Marcela Pekna, Univ. of Gothenburg, Sweden

Speakers

• Niki M. Moutsopoulos, NIDCR, NIH, Innate immunity and the oral mucosa
• Markus Bosmann, Boston Univ., Take a breath: local complement in lung pathologies
• Marcela Pekna, Univ. of Gothenburg, Sweden, C3a receptor signaling in neural plasticity and astrocyte-microglia crosstalk after CNS injury
• Brahm H. Segal, Univ. at Buffalo, SUNY, The unexpected contributions of local complement in ovarian cancer

Improved Tools for Modeling Human Immunity In Vitro and In Vivo—Organoid Cultures and Novel Mouse Models

Chairs

• Joy Liu, NIAID, NIH
• Mark T. Heise, Univ. of North Carolina at Chapel Hill

Speakers

• Mark T. Heise, Univ. of North Carolina at Chapel Hill, Complex genetic architecture underlies regulation of respiratory virus immune responses in the collaborative cross
• Huimin Zhang, Stanford Univ. Med. Sch., Modeling tissue-resident immunity in organoids
• Barbara Rehermann, NIDDK, NIH, Wild mouse microbiota in preclinical models of inflammation and metabolism
• Suhas Sureshchandra, Univ. of California, Irvine, Modeling human adaptive immune responses with tonsil organoids
• Paolo Casali, UT Health, San Antonio, Long Sch. of Med., Construction of mice with a fully human immune system mounting class-switched, hypermutated, and neutralizing antibody response

Somatic Mutations in Non-malignant Diseases

Chairs

• Peter C. Grayson, NIAMS, NIH
• Bhavisha A. Patel, NHLBI, NIH

Speakers

• Heather E. Machado, Sanger Inst., U.K., Mutational landscapes in human lymphocytes
• Peter C. Grayson, NIAMS, NIH, Somatic mutations in rheumatology: VEXAS syndrome and beyond
• Bhavisha A. Patel, NHLBI, NIH, Somatic mutations in benign hematologic diseases

Building the Antitumor Repertoire

Chairs

• Lisa H. Butterfield, Univ. of California, San Francisco
• Stephen P. Schoenberger, La Jolla Inst. for Immunology

Speakers

• Lisa H. Butterfield, Univ. of California, San Francisco, Dendritic cell dysfunction and making better vaccines
• Stephen P. Schoenberger, La Jolla Inst. for Immunology, ACT with NeoAg-specific CD4⁺ T cells
• Neeha Zaidi, Johns Hopkins Univ., Ras antigen vaccines, GVAX vaccines, and pancreatic cancer combinations
• Gordon J. Freeman, Dana-Farber Cancer Inst., Checkpoint modulation of the T cell repertoire

Understanding and Modulating Cytokine Activity through Structural Knowledge

Chairs

• Juan L. Mendoza, Univ. of Chicago
• Ignacio Moraga, Univ. of Dundee, Univ. of Dundee, United Kingdom

Speakers

• Matthew C. Franklin, Regeneron Pharma., Structural insights into the assembly of gp130 family cytokine signaling complexes
• Juan L. Mendoza, Univ. of Chicago, The native JAK-JAK geometry in the type III IFN signaling complex limits the functional potency
• Dylan Daniel, CytomX Therapeut., Designing conditionally activated probody cytokines to localize antitumor activity to cancers
• Ignacio Moraga, Univ. of Dundee, United Kingdom, Manipulating cytokine activities in different extracellular microenvironments
• Jamie B. Spangler, Johns Hopkins Univ., Dissecting immune biology using de novo engineered cytokines

Novel Strategies for the Prevention and Therapy of SARS-CoV-2 Infection

Chairs

• Shie-Liang Hsieh, Genomics Res. Ctr., Academia Sinica, Taiwan
• Jenny P.-Y. Ting, Univ. of North Carolina at Chapel Hill

Speakers

• Shie-Liang Hsieh, Genomics Res. Ctr., Academia Sinica, Taiwan, Targeting the CLEC2- CLEC5A/TLR2 axis to attenuate SARS-CoV-2-induced immunothrombosis
• Kuo-I Lin, Genomics Res. Ctr., Academia Sinica, Taiwan, Vaccination with a glyco-engineered SARS-CoV-2 spike protein confers cross-strain protection in mice
• Shih-Jen Liu, Nat. Hlth. Res. Inst., Taiwan, Strategies of DNA vaccination against COVID-19
• Che-Ming Hu, Inst. of Biomedical Sci., Academia Sinica, Taiwan, Breaking down the T cell induction barrier with modular nanotechnology for anticancer and antiviral applications

The Ontogeny and Functioning of the Immune System: Lessons from Non-mammalian Systems

Chairs

• Edan Foley, Univ. of Alberta, Canada
• Jason N. Berman, Univ. of Ottowa and Children's Hosp. of Eastern Ontario Res. Inst., Canada

Speakers

• Edan Foley, Univ. of Alberta, Canada, Single-cell resolution of the zebrafish intestinal immune response to a Vibrio cholerae infection
• Jason N. Berman, Univ. of Ottowa and Children's Hosp. of Eastern Ontario Res. Inst., Canada, Leveraging the zebrafish model for preclinical studies of the immune microenvironment in cancer
• Francesca Di Cara, Dalhousie Univ., Canada, Drosophila immunity
• Shayan Sharif, Univ. of Guelph, Canada, Chicken immunity and viral pathogens
• W. Brent Derry, Univ. of Toronto, Canada, C. elegans innate immunity

Immune Cell Communications in Cancer and Inflammation

Chairs

• Minsoo Kim, Univ. of Rochester
• Su-Hyung Park, Korea Advanced Inst. of Sci. and Tech., South Korea

Speakers

• Eun D. Lee, Virginia Commonwealth Univ., Targeting ERAP2 for cancer therapy
• Eun Young Choi, Seoul Nat. Univ. Col. of Med., South Korea, Actin and microtubule cross-talks in immune synapse and the application to CAR T cell therapy
• Chang-Duk Jun, Gwangju Inst. of Sci. and Tech., South Korea, T cell microvilli shedding as a mechanism of T cell clonal expansion
• Myong-Hee Sung, NIA, NIH, Double knock-in reporter mice reveal NF-κβ trajectories in signaling, immune cell development, and aging

Cutting Edge Research in Transplantation Tolerance, Rejection, and Infection

Chairs

• Valeria R. Mas, Univ. of Maryland Sch. of Med.
• Leonardo V. Riella, Massachusetts Gen. Hosp.

Speakers

• Keri E. Lunsford, Rutgers New Jersey Med. Sch., Liver transplant multi-omic assessment of immune frailty
• Anoma Nellore, Univ. of Alabama at Birmingham, Mucosal flu-specific B cells: insights from vaccine and ex vivo lung perfusion studies
• Mandy L. Ford, Emory Univ., Risky memory T cell subsets in transplantation
• Paolo Cravedi, Icahn Sch. of Med. at Mount Sinai, Inducing regulatory T cells for allograft survival

Immunoparasitology: Perspectives by Top Trainees, Early Career, and Established ASTMH Researchers

Chairs

• Robin Stephens, Rutgers New Jersey Med. Sch.
• Azza Hussein Idris, NIAID, NIH

Speakers

• Romaniya Zayats, Univ. of Manitoba, Canada, Cellular dynamics of immune evasion during Leishmania major infection
• Kirk D. C. Jensen, Univ. of California, Merced, Regulation of humoral immunity to Toxoplasma gondii
• Azza Hussein Idris, NIAID, NIH, Antibodies for malaria prevention—a bench to bedside story
• Robin Stephens, Rutgers New Jersey Med. Sch., CD4⁺ T cell regulation of immunity to plasmodium parasites

How the Latest Advances in Immunology Inform the Field of Developmental Immunotoxicology: A Panel Discussion

This symposium will feature brief talks and a panel discussion between basic and developmental immunologists and immunotoxicologists to learn from and inform each other of new scientific paradigms, advances, and methodology in their respective fields.

Chairs

• Michael C. Humble, NIEHS, NIH
• Fenna C.M. Sillé, Johns Hopkins Univ.

Panelists

• Michael C. Humble, NIEHS, NIH, Introduction
• Anna E. Beaudin, Univ. of Utah, Contribution of fetal hematopoiesis to postnatal immune function and disease susceptibility
• Jamie C. DeWitt, East Carolina Univ., Impact of early-life exposure to per- and polyfluoroalkyl substances (PFAS) and implications for later life immune-based diseases
• Isha Khan, Michigan State Univ., An in vitro model of human hematopoiesis for developmental immunotoxicity testing
• Brian D. Rudd, Cornell Univ., Studying immune development in mice with normalized microbial exposure
• Momoko Yoshimoto-Kobayashi, Univ. of Texas Hlth. Sci. Cntr. at Houston, HSC-independent hematopoiesis in the embryo contributes to a significant part of adult immune cell
• Judith T. Zelikoff, New York Univ. Langone Health, Pulmonary immunotoxic effects of inhaled ambient particulate matter on prenatally-exposed offspring
• Fenna C.M. Sillé, Johns Hopkins Univ., Panel discussion: future outlook on alternatives to DIT testing

Fundamental Lessons Learned from the Clinic

Chairs

• Bojan Polić, Univ. of Rijeka, Croatia
• Rami Bechara, Université Paris-Saclay, France

Speakers

• Bojan Polić, Univ. of Rijeka, Croatia, Immune-endocrine regulation of blood glucose in a strong non-lethal viral infection
• Eva Martínez-Cáceres, Germans Trias i Pujol Hosp., Badalone, Spain, Cell-based tolerogenic therapies: from bench to bedside, and back
• Luke A.J. O'Neill, Trinity Col., Dublin, Ireland, Macrophage immunometabolism and the regulation of inflammation
• S. Marieke van Ham, Sanquin Res., Netherlands, Insights into human B cell differentiation upon infection and vaccination
• David C. Wraith, University of Birmingham, United Kingdom, The mechanism of antigen-specific immunotherapy of autoimmune diseases